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The role of long noncoding RNA H19 in the pathogenesis of polycystic ovary syndrome
2025-12-08

Polycystic ovary syndrome (PCOS) is a common endocrine disorder accounting for ~70–80% of cases of female annovulatory infertility. Genetic factors, including non-coding RNAs, are involved in the etiology of PCOS. The aim of this paper is to systematize experimental and clinical data on the role of long non-coding RNA H19 in the pathogenesis of PCOS, to consider patterns of dysregulation and impact of H19 on steriogenesis in the blood, follicular fluid, cumulus and granulosa cells; to analyze associations of H19 polymorphisms with the risk of PCOS development; and to assess the potential of H19 as a diagnostic and therapeutic target. The obtained data indicate that H19 is stably dysregulated in the blood, follicular fluid, granulosa/cumulus cells in patients with PCOS. H19 integrates key links of pathogenesis: ovarian function (H19/let 7→AMH axis), inflammation and granulosa cell pyroptosis (H19/miR 29a 3p→NLRP3/HDAC1 axis), cell proliferation (H19/miR 19b→CTGF), steroidogenesis (CYP17A1 and testosterone), and STAT3 signaling. An association of the rs2067051 genetic variant of the H19 gene with the risk of developing PCOS in certain populations has been shown.

Ссылка для цитирования:

Lomteva S. V. 2025. The role of long noncoding RNA H19 in the pathogenesis of polycystic ovary syndrome. PREPRINTS.RU. https://doi.org/10.24108/preprints-3114020

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