This study rigorously explores the pivotal role of Key Performance Indicators (KPIs) in advancing airline safety management, addressing the necessity for a systematic, data-driven approach to enhancing safety measures, compliance, and culture within the airline industry. Through a mixed-methods research design combining quantitative analysis of safety performance data and qualitative insights from industry professionals, the study identifies and evaluates a comprehensive set of safety KPIs integral to operational safety, regulatory adherence, and the promotion of a proactive safety culture. The findings reveal that specific KPIs, notably those related to proactive safety actions and employee safety engagement, significantly contribute to improving safety protocols and outcomes. By integrating these KPIs into their safety management systems, airlines can not only meet but exceed regulatory standards, setting new benchmarks for safety excellence. The research underscores the strategic importance of KPIs in facilitating a proactive, anticipatory approach to safety management, moving beyond compliance to foster continuous improvement and a robust safety culture. This study contributes to both theoretical frameworks and practical applications in airline safety management, offering actionable insights for Chief Safety Officers and delineating future research directions to further enhance airline safety standards.