Роль микроРНК, регулирующих гены окислительного стресса, при синдроме поликистозных яичников

Светлана Витальевна Ломтева,Артур Сергеевич Сагомонов,Евгения Юрьевна Харченко

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Роль микроРНК, регулирующих гены окислительного стресса, при синдроме поликистозных яичников

С. В. Ломтева,

А. С. Сагомонов,

Е. Ю. Харченко

2025-12-08

https://doi.org/10.24108/preprints-3114011

Синдром поликистоза яичников (СПЯ) часто сочетается с хроническим окислительным стрессом, нарушающим инсулиновую сигнализацию и оогенез. Цель исследования: Систематизировать микроРНК, непосредственно регулирующие гены окислительного стресса при СПЯ. Методы: Анализ публикаций за последние 25 лет для сопоставление мишеней микроРНК с путями антиоксидантной защиты с использованием баз данных: HMDD, PCOSKB и miRTargetLink 2.0. Результаты: miR-145 подавляет пролиферацию гранулёзных клеток, ингибируя сигнальный путь IRS1/MAPK ERK; miR-16 воздействует на PDCD4 и подавляет апоптоз; miR-323-3p регулирует гены IGF1/PDCD4; miR-324-3p регулирует пролиферацию и апоптоз в гранулезных клетках посредством воздействия на ген WNT2B; miR-222 подавляет экспрессию SOD2; miR-27a участвует в фолликулогенезе, регулирует ген Nrf2; miR-93 подавляет активность антиоксидантного гена NFE2L2 и стимулирует апоптоз; miR-21 участвует в развитии фолликулов и стероидогенезе, усиливакет продукцию активных форм кислорода и подавляет активность SOD2 и SOD3. Заключение: Показано, что miR-145; miR-323-3p; miR-324-3p; miR-146a; miR-93 и miR-21 могут служить диагностическими/прогностическими маркерами и мишенями терапии СПЯ, что в конечном итоге может улучшить фертильность, метаболическое здоровье и качество жизни у женщин с СПЯ.

Ссылка для цитирования:

Ломтева С. В., Сагомонов А. С., Харченко Е. Ю. 2025. Роль микроРНК, регулирующих гены окислительного стресса, при синдроме поликистозных яичников. PREPRINTS.RU. https://doi.org/10.24108/preprints-3114011

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